Research overview

MOTS-C Mitochondrial-Derived Peptide

MOTS-c is a mitochondrial-derived peptide studied for AMPK activation, insulin sensitivity, and metabolic regulation in cellular research.

Compound profile

Name: MOTS-C
Scientific name: Mitochondrial-Derived Peptide
Molecular formula: C101H152N28O22S2
Molecular weight: 2174.6 g/mol
Category: Research peptide (research use only)
Documentation: Third-party tested; per-batch COA when available

Certificates of Analysis

Scientific literature

12 curated peer-reviewed studies and public references for MOTS-C. Each opens at its original source; provided for research reference only.

Free Radical Biology and Medicine · 2025

Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretion

Journal of Translational Medicine · 2023

Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging

Frontiers in Endocrinology · 2023

MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation

Diabetes & Metabolism Journal · 2022

Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)

Physiological Reports · 2022

MOTS-c increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose

Nature Communications · 2021

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Alzheimer's Drug Discovery Foundation · 2021

MOTS-c Cognitive Vitality Report

Physiol Rep · 2019

The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity

ClinicalTrials.gov · 2019

A Phase 1a/1b Study of CB4211 in Healthy Non-obese Subjects and Subjects With Nonalcoholic Fatty Liver Disease

Pediatric Diabetes · 2018

Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance

Cell Metabolism · 2015

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Aging Cell · 2015

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

Literature last updated July 27, 2026

For Research Use Only

All products currently listed on this site are for research purposes only. Not for human or animal consumption. Intended strictly for qualified laboratories performing controlled in-vitro or analytical research. No medical, diagnostic, or therapeutic claims are made for any product. The references above are provided for research reference only and do not constitute claims about any product sold here.

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