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Wolverine BPC-157 / TB-500 Wolverine is a co-formulated blend of BPC-157, a synthetic pentadecapeptide studied for cytoprotective and angiogenic signaling pathways, and TB-500, a thymosin beta-4 fragment studied for actin-binding and cell-migration processes, in research models.
Compound profile
Name Wolverine
Scientific name BPC-157 / TB-500
Molecular formula BPC-157: C62H98N16O22 · TB-500: C212H350N56O78S
Molecular weight BPC-157: 1419.5 g/mol · TB-500: 4963.4 g/mol
Category Research peptide (research use only)
Documentation Third-party tested; per-batch COA when available Scientific literature 11 curated peer-reviewed studies and public references for Wolverine. Each opens at its original source; provided for research reference only.
GlobalRPH Clinical Review · 2025
BPC-157 and TB-500: Background, Indications, Efficacy, and Safety
HSS Journal (NIH/PubMed Central) · 2025
Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review
Source
HSS Journal (NIH/PubMed Central)
DOI
10.1177/15563316251355551
Domain
pmc.ncbi.nlm.nih.gov
Authors
Vasireddi N, Hahamyan H, Salata MJ, Karns M, Calcei JG, Voos JE, Apostolakos JM
View source Frontiers in Endocrinology · 2021
Progress on the Function and Application of Thymosin β4
Source
Frontiers in Endocrinology
DOI
10.3389/fendo.2021.767785
Domain
pmc.ncbi.nlm.nih.gov
View source Scientific Reports (Nature) · 2020
Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway
Source
Scientific Reports (Nature)
DOI
10.1038/s41598-020-74022-y
Authors
Hsieh MJ, Lee CH, Chueh HY, et al.
View source Regulatory Toxicology and Pharmacology · 2020
Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds
Source
Regulatory Toxicology and Pharmacology
DOI
10.1016/j.yrtph.2020.104665
Domain
pubmed.ncbi.nlm.nih.gov
Authors
Xu C, Sun L, Ren F, et al.
View source ClinicalTrials.gov · 2015
PCO-02 - Safety and Pharmacokinetics Trial
Expert Opinion on Biological Therapy · 2012
Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications
Source
Expert Opinion on Biological Therapy
DOI
10.1517/14712598.2012.634793
Domain
pubmed.ncbi.nlm.nih.gov
Authors
Goldstein AL, Hannappel E, Sosne G, Kleinman HK
View source Journal of Applied Physiology · 2011
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
Source
Journal of Applied Physiology
DOI
10.1152/japplphysiol.00945.2010
Domain
journals.physiology.org
Authors
Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH
View source Annals of the New York Academy of Sciences · 2010
A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers
Source
Annals of the New York Academy of Sciences
DOI
10.1111/j.1749-6632.2010.05474.x
Domain
pubmed.ncbi.nlm.nih.gov
Authors
Ruff D, Crockford D, Girardi G, Zhang Y
View source Nature · 2004
Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Domain
pubmed.ncbi.nlm.nih.gov
Authors
Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D
View source Journal of Investigative Dermatology · 1999
Thymosin beta4 accelerates wound healing
Source
Journal of Investigative Dermatology
DOI
10.1046/j.1523-1747.1999.00708.x
Domain
pubmed.ncbi.nlm.nih.gov
Authors
Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK
View source Literature last updated July 25, 2026
For Research Use Only All products currently listed on this site are for research purposes only. Not for human or animal consumption. Intended strictly for qualified laboratories performing controlled in-vitro or analytical research. No medical, diagnostic, or therapeutic claims are made for any product. The references above are provided for research reference only and do not constitute claims about any product sold here.
Wolverine — research grade, third-party tested
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